Table 3. Metabolism of test compounds by D. melanogaster S2 cells expressing CYP6CY22(c21228_g1) and CYP6CY13 (c21368_g1) genes.

	c21228_g1 (CYP6CY22)			c21368_g1 (CYP6CY13)			RF1b)	RF2c)
	%Recovery (avg.±S.D.)a)		%Metab.	%Recovery (avg.±S.D.)a)		%Metab.
	Control	+transfection		Control	+transfection
Acetamiprid	102.2±0.2	26.0±0.1	84.0	99.5±1.0	38.8±1.0	61.2	65.4	104
Thiacloprid	99.8±0.7	8.5±0.7	91.5	95.6±0.3	32.8±0.8	67.2	23.8	17
Sulfoxaflor	99.6±0.6	95.6±0.6	4.4	101.2±1.9	98.3±2.8	1.7	22.6
Imidacloprid	101.5±0.4	7.5±0.4	92.5	98.5±1.2	60.0±1.0	40.0	216	253
Clothianidin	98.2±1.5	55.2±3.0	44.8	96.5±0.4	74.5± 1.1	25.5	394	687
Thiamethoxam	95.6±1.1	42.8±1.3	57.2	98.2±0.2	69.3±0.3	30.7	295	246
Nitenpyrum	97.5±1.2	69.3±1.0	30.7	96.5±1.3	77.1±2.3	22.9	253	43
Dinotefuran	103.4±1.2	55.8±5.9	44.2	101.3±2.1	51.2±7.5	48.8	237	199

^a) % Recovery 72 hr after incubation compared with time 0. Data represent the mean±SD (n=3). ^b) Resistance factor (LC₅₀ MK clone/LC₅₀ NS clone). The resistance factor of sulfoxaflor was determined by method described previously.^{12) c)} Resistance factor (LC₅₀ MK clone/LC₅₀ MS clone).²⁴⁾