Figure 2.

CD100 is involved in many important steps of atherogenesis. CD100 binding to plexin B2 at the cell surface monocytes and to plexin B1 on endothelial cells (ECs) promotes cell adhesion (A) and may facilitate monocyte transmigration. Platelets express CD100 and receptors CD72 and plexin B1, which are directly involved in platelet binding to ECs (B) and in platelet aggregation (C) and thrombus formation. sCD100 induces angiogenesis by binding to plexin B1 in ECs (B). However, CD100 also presents atheroprotective roles, such as the reduction of oxLDL capture by macrophages through downregulation of scavenger receptor CD36 (D). References as cited in Table 1.