Table 2.

TWO point LOD score analysis reflecting linkage between LGMD/PDB disease and known disease loci^*

Marker	MIM Number²	Locus	Chromosome	0.00	0.01	0.02	0.03	0.04	0.05	0.10	0.20	0.30	0.40	Exclusion
D5S479	159000	LGMD1A	5q22.3–q31.1	−9.96	−4.29	−3.55	−3.09	−2.76	−2.49	−1.63	−0.77	−0.33	−0.09	7.05 cM
D5S500	159000	LGMD1A	5q22.3–q31.1	−6.47	−3.30	−2.68	−2.30	−2.03	−1.82	−1.14	−0.51	−0.23	−0.08	4.01 cM
D1S305	159001	LGMD1B/CDCD1	1q11–q21	−9.72	−4.29	−3.49	−2.99	−2.63	−2.35	−1.46	−0.62	−0.24	−0.06	6.03 cM
APOA2	159001	LGMD1B/CDCD1	1q11–q21	−14.04	−7.11	−5.71	−4.88	−4.28	−3.82	−2.42	−1.11	−0.46	−0.12	12.24 cM
D3S1263	601253	LGMD1C/CDCD2	3p25	−11.05	−5.30	−4.39	−3.80	−3.36	−3.01	−1.88	−0.82	−0.33	−0.09	9.10 cM
D7S550	603511	LGMD1D	7q	−7.74	−4.28	−3.56	−3.12	−2.80	−2.54	−1.74	−0.91	−0.43	−0.15	7.05 cM
D2S138	603689	Edström’s myopathy	2q24–q31	−6.75	−0.27	0.11	0.33	0.48	0.59	0.83	0.79	0.50	0.17	On marker
D2S1245	603689	Edström’s myopathy	2q24–q31	−3.58	−0.63	−0.24	−0.01	0.15	0.26	0.53	0.51	0.26	0.06	On marker
D21S1255	105400	ALS1	21q22.1	−6.69	−3.04	−2.48	−2.10	−1.82	−1.59	−0.87	−0.28	−0.09	−0.04	3.00 cM
D15S778	253600	LGMD2A	15q15.1–q21.1	−2.70	−1.17	0.87	−0.68	−0.55	−0.44	−0.09	0.17	0.18	0.08	On marker
D2S2113	253601	LGMD2B	2p13–p16	−16.53	−5.12	−3.93	−3.23	−2.75	−2.38	−1.28	−0.39	−0.07	0.00	6.03 cM
D13S115	253700	LGMD2C	13q12	−6.55	−3.30	−2.71	−2.34	−2.06	−1.84	−1.13	−0.48	−0.18	−0.05	4.00 cM
ADL	600119	LGMD2D	17q21	−5.73	−2.74	−2.18	−1.80	−1.51	−1.28	−0.55	0.04	0.16	0.09	2.00 cM
D4S2690	604286	LGMD2E	4q12	−4.24	−1.05	−0.72	−0.51	−0.36	−0.25	0.09	0.28	0.23	0.08	On marker
D5S470	601287	LGMD2F	5q33−q34	−12.58	−4.49	−3.73	−3.26	−2.90	−2.62	−1.72	−0.83	−0.35	−0.10	8.07 cM
D17S1818	601954	LGMD2G	17q11–q12	−8.93	−3.42	−2.82	−2.48	−2.23	−2.04	−1.42	−0.70	−0.27	−0.06	5.02 cM
D17S250	601954	LGMD2G	17q11–q12	−10.97	−7.50	−6.23	−5.42	−4.82	−4.34	−2.80	−1.31	−0.57	−0.17	14.38 cM
D9S302	254110	LGMD2H	9q31–q33	−11.67	−4.37	−3.54	−3.02	−2.65	−2.36	−1.52	−0.85	−0.52	−0.23	6.03 cM
D6S105	167250	PDB1	6p21.2	−9.93	−4.31	−3.63	−3.19	−2.86	−2.59	−1.67	−0.72	−0.26	−0.05	7.05 cM
D18S60	602080	PDB2	18q21–q22	−4.76	−2.04	−1.71	−1.52	−1.37	−1.26	−0.89	−0.47	−0.21	−0.05	1.00 cM
D18S42	602080	PDB2	18q21–q22	−9.06	−4.72	−3.94	−3.44	−3.06	−2.76	−1.77	−0.79	−0.31	−0.07	8.07 cM
D9S152	600884	CMD1B	9q13–q22	−7.70	−1.53	−1.19	−0.99	−0.84	−0.72	−0.35	−0.03	0.06	0.05	On marker
D9S153	600884	CMD1B	9q13–q22	−7.88	−1.42	−1.07	−0.87	−0.72	−0.61	−0.28	−0.05	−0.01	−0.02	On marker
D10S201	601493	CMD1C	10q21–q23	−13.09	−4.98	−4.12	−3.57	−3.16	−2.83	−1.79	−0.79	−0.30	−0.06	8.07 cM
D1S414	601493	CMD1D	1q32	−5.31	−0.79	−0.25	0.05	0.24	0.38	0.70	0.71	0.47	0.19	On marker
D6S262	602067	CMD1F/CDCD3	6q23	−5.42	−1.67	−1.30	−1.05	−0.87	−0.71	−0.22	0.16	0.20	0.10	On marker
D6S1040	602067	CMD1F/CDCD3	6q23	−5.93	−3.06	−2.52	−2.16	−1.90	−1.69	−1.02	−0.42	−0.14	−0.03	3.00 cM

CDCD, cardiomyopathy, dilated, conduction defect; CMD, cardiomyopathy, dilated.