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The JES6–1 antibody chains on which the mutations are located are indicated in parentheses.
| Construct | KD of IL-2/Antibody Complex (nM) | KD of IL-2Rα/IC Complex (nM) |
|---|---|---|
| JES6–1 | 5.6 | 290 |
| D55A (VH) | 500 | 230 |
| D58A (VH) | 200 | 260 |
| E60A (VH) | 56 | 210 |
| R62A (VH) | 4.3 | 190 |
| S34A (VL) | 6.5 | 170 |
| Y41A (VL) | 6.4 | 130 |
| H100A (VL) | 62 | 240 |
| Y101A (VL) | 12 | 140 |
