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All mutations are located on the JES6–1 variable light chain.
| Construct | KD of IL-2Rα/IC Complex (nM) |
|---|---|
| JES6–1 | 220 |
| S34A+Y41A | 210 |
| S34A+Y101A | 82 |
| Y41A+Y101A | 82 |
| S34A+Y41A+Y101A | 130 |
