Table 1.
Trial | Specified eligibility criteria | Random allocation | Concealed allocation | Similarity at baseline on key measures | Subject blinding | Therapist blinding | Assessor blinding | >85% follow-up of at least one key outcome | Intention-to treat analysis | Between-group statistical comparison for at least one key outcome | Point estimates and measures of variability provided for at least one key outcome | Total |
Asthma | ||||||||||||
Ahmaidi et al (1993)28 | ✓ | ✓ | x | X | NA | NA | X | X | X | ✓ | ✓ | 4 |
Andrade et al (2014)29 | ✓ | ✓ | ✓ | ✓ | NA | NA | X | X | ✓ | ✓ | ✓ | 7 |
Basaran et al (2006)30 | X | ✓ | X | ✓ | NA | NA | X | ✓ | X | ✓ | ✓ | 5 |
Chang et al (2008)32 | X | ✓ | X | ✓ | NA | NA | X | X | X | ✓ | ✓ | 4 |
Counil et al (2003)33 | ✓ | ✓ | X | ✓ | NA | NA | ✓ | ✓ | X | ✓ | ✓ | 7 |
Edenbrandt et al (1990)35 | X | ✓ | X | ✓ | NA | NA | X | ✓ | ✓ | ✓ | ✓ | 6 |
Fanelli et al (2007)36 | ✓ | ✓ | ✓ | ✓ | NA | NA | ✓ | ✓ | ✓ | ✓ | ✓ | 9 |
Latorre-Román et al (2014)40 | ✓ | ✓ | X | ✓ | NA | NA | X | ✓ | X | ✓ | ✓ | 6 |
Matsumoto et al (1999)41 | X | ✓ | X | ✓ | NA | NA | X | ✓ | ✓ | ✓ | ✓ | 6 |
Moreira et al (2008)42 | ✓ | ✓ | ✓ | ✓ | NA | NA | X | ✓ | ✓ | ✓ | ✓ | 8 |
Onur et al (2011)43 | ✓ | ✓ | X | ✓ | NA | NA | X | ✓ | ✓ | ✓ | ✓ | 7 |
Silva et al (2006)49 | ✓ | ✓ | X | ✓ | NA | NA | X | ✓ | ✓ | ✓ | ✓ | 7 |
Silva et al. (2013)50 | X | ✓ | X | ✓ | NA | NA | X | ✓ | X | ✓ | ✓ | 5 |
Van Veldhoven et al. (2001)51 | ✓ | ✓ | X | ✓ | NA | NA | X | ✓ | X | ✓ | ✓ | 6 |
Wang et al (2009)52 | X | ✓ | X | ✓ | NA | NA | X | ✓ | ✓ | ✓ | ✓ | 6 |
Weisgerber et al (2003)53 | ✓ | ✓ | X | ✓ | NA | NA | X | X | X | ✓ | ✓ | 5 |
Wicher et al (2010)54 | ✓ | ✓ | X | ✓ | NA | NA | X | ✓ | X | X | ✓ | 5 |
Cystic fibrosis | ||||||||||||
Cerny et al (1989)31 | X | ✓ | X | X | NA | NA | X | ✓ | ✓ | ✓ | ✓ | 5 |
De Oliveira et al (2009)34 | ✓ | ✓ | X | ✓ | NA | NA | X | X | X | ✓ | ✓ | 5 |
Hebestreit et al (2010)37 | ✓ | ✓ | X | ✓ | NA | NA | X | ✓ | X | ✓ | ✓ | 6 |
Hommerding et al (2015)38 | ✓ | ✓ | X | ✓ | NA | NA | X | ✓ | ✓ | ✓ | ✓ | 7 |
Klijn et al (2004)39 | ✓ | ✓ | ✓ | ✓ | NA | NA | ✓ | ✓ | X | ✓ | ✓ | 8 |
Santana Sosa et al (2012)44 | ✓ | ✓ | X | ✓ | NA | NA | ✓ | ✓ | ✓ | ✓ | ✓ | 8 |
Santana Sosa et al (2014) | ✓ | ✓ | X | ✓ | NA | NA | ✓ | ✓ | ✓ | ✓ | ✓ | 8 |
Schindel et al (2015)46 | ✓ | ✓ | X | ✓ | NA | NA | ✓ | ✓ | ✓ | ✓ | ✓ | 8 |
Schneiderman-Walker et al (2000)47 | X | ✓ | X | ✓ | NA | NA | X | ✓ | X | ✓ | ✓ | 5 |
Selvadurai et al (2002)48 | ✓ | ✓ | ✓ | ✓ | NA | NA | X | ✓ | ✓ | ✓ | ✓ | 8 |