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Normalized expression of a selection of genes regulated by active FXR-RXR dimers in HepaRG cells exposed for 24 h to bosentan in IC10 concentration.
| Gene | Fold change (bosentan versus control) |
p-value (Fisher’s Exact) |
|---|---|---|
| ABCB4 | -2.9 | 5.93E-05 |
| HNF4A | -2.0 | 1.15E-03 |
| MTTP | -4.7 | 8.88E-03 |
| NR1H4 | -2.4 | 2.06E-03 |
| PCK2 | -2.5 | 9.33E-03 |
| PON1 | -4.4 | 5.79E-03 |
| PPARG | -2.1 | 2.90E-02 |
| PPARGC1A | -2.6 | 6.84E-05 |
| SLC51A | 3.0 | 2.29E-02 |
| SLCO1B1 | -2.6 | 7.90E-06 |
| UGT2B4 | -5.1 | 7.50E-04 |
