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. Author manuscript; available in PMC: 2018 Nov 20.
Published in final edited form as: Free Radic Biol Med. 2018 Feb 2;128:50–58. doi: 10.1016/j.freeradbiomed.2018.01.027

Fig. 3. Basic principle of CR-geNOp.

Fig. 3

The CR-geNOps consists of the NO sensitive CFP and the NO insensitive RFP. Due to the different chromophore and the distance to the NO binding GAF domain, the fluorescence of the RFP remains unaffected by NO. Accordingly, the probe can be used as a (pseudo) ratiometric NO sensor.