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. 2018 Sep 11;9(71):33589–33600. doi: 10.18632/oncotarget.26096

Figure 5. Hindering protective mechanisms against DNA damage renders ER+ cells more sensitive toward YM155.

Figure 5

(A and B) Both cell lines were treated with YM155 (40 nM for T47D and 50 nM for BT474), BSO (including 15 h pretreatment with 0.5 mM), AZD7762 (50 nM) and all three for 72 h and subjected to CellTiter-Glo assay for measurement of cell viability). YM155 versus YM155+BSO+AZD7762 comparison is statistically significant at P < 0.05 (2.35411E-07: (A); 1.04E-05: (B)) (C) Immunoblot comparing survivin expression levels in T47D and BT474 following 40 nM and 50 nM YM155 exposure, respectively for 72 h. (D) Schematic representation of the mode of action of YM155 on BC cells as established from this study.