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. 2018 Sep 11;9(71):33446–33458. doi: 10.18632/oncotarget.26002

Figure 5. RN765C is more efficacious than standard of care in multiple NSCLC PDX models.

Figure 5

(A) CTG1014 PDX model carries EGFR L858R/T790M mutations, 4 mice per group. (B) LG1179 is a Kras G13R mutant PDX model, 4 mice per group. (C) LG0551 is a squamous cell carcinoma PDX model, 5 mice per group. Colored arrows represent the dosing frequency of the treatment with the corresponding symbol colors. In brief, cetuximab and paclitaxel were given once a week for 2 weeks; carboplatin was given once a week for 2 weeks in (A) and (C), for 3 weeks in (B); gemcitabine was given twice a week for 2 weeks in (A), for 3 weeks in (B).