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. 2018 Aug 7;7(10):764–771. doi: 10.1002/open.201800112

Scheme 2.

Scheme 2

Cyclization attempt by using the Pictet–Spengler reaction of aminonitrile 11. Reagents and conditions. a) Cp2ZrHCl, THF, −20 to 0 °C, 1 h; aq KCN, 25 °C, 4 h, 96 %. Cp=η5‐cyclopentadienyl.