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. 2018 Oct 5;13(10):e0198231. doi: 10.1371/journal.pone.0198231

Fig 1. Structural analysis of GAS5 gene.

Fig 1

(A) Chromosomal localization of GAS5 gene. It is present on chromosome 1q25.1, at genomic coordination 1:173863901–173867987 on the negative strand (according to human genome assembly GRCh38). (B) Sequence analysis of GAS5 gene. It consists of 12 exons, spanning 4.087 kb that code for 29 different alternative splice transcripts. It hosts multiple snoRNA genes within its introns (except intron 9). These genes encode for ten C/D box snoRNAs, which contain the C (UGAUGA) and D (CUGA) box motifs, and an H/ACA box snoRNA, SNORDA103, within intron 4. (C) Genetic variant analysis. GAS5 gene (4087 bases long) contains around 300 thousand variants (75% intronic, 21% exonic, and 4% splice region polymorphisms). Among all these polymorphisms, 14 SNPs (red), one deletion (green) and one insertion (blue) are common variants with minor allele frequency (MAF) > 0.05. (D) Subcellular localization of lncRNA GAS5. Text mining highlighted its predominant existence intranuclear and within extracellular exosomes which are extruded into the circulation. (E) Folding pattern of lncRNA GAS5. [Data source: Ensembl.org, genecards.org, NCBI, COMPARTMENT database, and MFold].