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. 2018 Sep 18;9(73):33778–33787. doi: 10.18632/oncotarget.26042

Figure 5. mRNA expression of EMT markers, stem cell markers as well as cell cycle arrest and cell proliferation in KATO-III after treatment with suramin.

Figure 5

Expression of heparanase (A), mesenchymal markers (Slug, Vimentin and α-SMA) (B) and stem cell markers (CXCR-4, OCT3/4 and NANOG) (C) were found lower while epithelial marker (E-cadherin) was found higher (B) in KATO-III after treatment with suramin by qPCR. Suramin inhibits the proliferation (D) and cell cycle arrest (E) in KATO-III after treatment. The data indicates the percentage of cells in each phase of the cell cycle (F). The results are expressed as mean ± SEM of six independent experiments *P < 0.05, **P < 0.01, and are statistically significant.