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. 2018 Jun 12;39(5):664–675. doi: 10.1210/er.2018-00087

Figure 1.

Figure 1.

Obligatory domain structure schematic. Drawing showing the six ERα domains, A to F, oriented from the amino (N) to carboxyl (C) terminus. The domains in which each of several key functions is located are indicated: AF-1 and AF-2 mediate transcriptional activity. The DBD interacts with ERE DNA motifs, and the LBD binds E2. Helix 12 (H12) interacts with transcriptional activators and repressors.