Table S1.
Univariate Cox regression analysis of chemokine family genes associated with disease-free survival in the training set (n=246, GSE39582)
| Gene symbol | Type | Sub-family | HR (95% CI) | Coefficient | P-value |
|---|---|---|---|---|---|
| CCL1 | Ligand | CC | 2.729 (1.118–6.662) | 1.004 | 0.027 |
| CCL2 | Ligand | CC | 1.169 (0.970–1.410) | 0.156 | 0.102 |
| CCL3 | Ligand | CC | 1.004 (0.844–1.194) | 0.004 | 0.962 |
| CCL4 | Ligand | CC | 1.019 (0.823–1.261) | 0.019 | 0.863 |
| CCL5 | Ligand | CC | 0.918 (0.757–1.114) | −0.085 | 0.387 |
| CCL7 | Ligand | CC | 1.118 (0.728–1.719) | 0.112 | 0.610 |
| CCL8 | Ligand | CC | 0.993 (0.830–1.190) | −0.007 | 0.943 |
| CCL11 | Ligand | CC | 1.019 (0.868–1.196) | 0.018 | 0.822 |
| CCL13 | Ligand | CC | 1.152 (0.743–1.784) | 0.141 | 0.527 |
| CCL14 | Ligand | CC | 1.400 (1.043–1.879) | 0.336 | 0.025 |
| CCL15 | Ligand | CC | 1.051 (0.823–1.344) | 0.050 | 0.688 |
| CCL16 | Ligand | CC | 1.556 (0.916–2.643) | 0.442 | 0.102 |
| CCL17 | Ligand | CC | 1.240 (0.699–2.203) | 0.215 | 0.462 |
| CCL18 | Ligand | CC | 0.987 (0.853–1.142) | −0.013 | 0.861 |
| CCL19 | Ligand | CC | 1.063 (0.902–1.252) | 0.061 | 0.467 |
| CCL20 | Ligand | CC | 0.885 (0.771–1.015) | −0.122 | 0.082 |
| CCL21 | Ligand | CC | 1.124 (0.924–1.366) | 0.117 | 0.242 |
| CCL22 | Ligand | CC | 0.877 (0.538–1.430) | −0.131 | 0.600 |
| CCL23 | Ligand | CC | 1.211 (0.701–2.090) | 0.191 | 0.492 |
| CCL24 | Ligand | CC | 1.132 (0.919–1.395) | 0.124 | 0.243 |
| CCL25 | Ligand | CC | 0.739 (0.466–1.172) | −0.302 | 0.199 |
| CCL26 | Ligand | CC | 0.938 (0.705–1.250) | −0.064 | 0.664 |
| CCL27 | Ligand | CC | 1.507 (0.673–3.373) | 0.410 | 0.319 |
| CCL28 | Ligand | CC | 1.058 (0.821–1.363) | 0.056 | 0.664 |
| CXCL1 | Ligand | CXC | 0.824 (0.697–0.974) | −0.194 | 0.024 |
| CXCL2 | Ligand | CXC | 0.870 (0.608–1.243) | −0.140 | 0.444 |
| CXCL3 | Ligand | CXC | 0.836 (0.708–0.986) | −0.179 | 0.034 |
| CXCL5 | Ligand | CXC | 0.939 (0.824–1.071) | −0.062 | 0.349 |
| CXCL6 | Ligand | CXC | 0.951 (0.810–1.115) | −0.051 | 0.534 |
| CXCL8 | Ligand | CXC | 0.933 (0.810–1.073) | −0.070 | 0.329 |
| CXCL9 | Ligand | CXC | 0.840 (0.722–0.977) | −0.174 | 0.024 |
| CXCL10 | Ligand | CXC | 0.832 (0.712–0.972) | −0.184 | 0.021 |
| CXCL11 | Ligand | CXC | 0.878 (0.774–0.995) | −0.131 | 0.041 |
| CXCL12 | Ligand | CXC | 1.107 (0.907–1.352) | 0.102 | 0.319 |
| CXCL13 | Ligand | CXC | 0.870 (0.763–0.992) | −0.140 | 0.037 |
| CXCL14 | Ligand | CXC | 1.146 (1.008–1.302) | 0.136 | 0.037 |
| CXCL16 | Ligand | CXC | 0.901 (0.650–1.249) | −0.104 | 0.531 |
| CXCL17 | Ligand | CXC | 0.814 (0.525–1.262) | −0.206 | 0.357 |
| XCL1 | Ligand | XC | 0.923 (0.524–1.627) | −0.080 | 0.782 |
| XCL2 | Ligand | XC | 1.004 (0.744–1.355) | 0.004 | 0.978 |
| CX3CL1 | Ligand | CX3C | 0.896 (0.613–1.312) | −0.109 | 0.574 |
| CCR1 | Receptor | CC | 1.079 (0.786–1.481) | 0.076 | 0.638 |
| CCR2 | Receptor | CC | 0.965 (0.632–1.475) | −0.035 | 0.870 |
| CCR3 | Receptor | CC | 1.001 (0.553–1.815) | 0.001 | 0.996 |
| CCR4 | Receptor | CC | 1.356 (0.600–3.062) | 0.304 | 0.464 |
| CCR5 | Receptor | CC | 0.861 (0.595–1.244) | −0.15 | 0.425 |
| CCR6 | Receptor | CC | 0.937 (0.622–1.411) | −0.065 | 0.756 |
| CCR7 | Receptor | CC | 0.880 (0.667–1.161) | −0.128 | 0.364 |
| CCR8 | Receptor | CC | 1.127 (0.429–2.960) | 0.119 | 0.808 |
| CCR9 | Receptor | CC | 1.190 (0.391–3.620) | 0.174 | 0.759 |
| CCR10 | Receptor | CXC | 1.239 (0.880–1.745) | 0.214 | 0.220 |
| CXCR1 | Receptor | CXC | 0.511 (0.211–1.240) | −0.671 | 0.138 |
| CXCR2 | Receptor | CXC | 1.005 (0.746–1.355) | 0.005 | 0.973 |
| CXCR3 | Receptor | CXC | 0.732 (0.373–1.438) | −0.312 | 0.365 |
| CXCR4 | Receptor | CXC | 0.979 (0.793–1.208) | −0.021 | 0.842 |
| CXCR5 | Receptor | CXC | 0.966 (0.412–2.267) | −0.034 | 0.937 |
| CXCR6 | Receptor | CXC | 0.803 (0.490–1.317) | −0.219 | 0.385 |
| XCR1 | Receptor | XC | 1.648 (0.515–5.274) | 0.499 | 0.400 |
| CX3CR1 | Receptor | CX3C | 1.569 (0.864–2.849) | 0.45 | 0.139 |