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. 2018 Sep 20;3(9):11455–11468. doi: 10.1021/acsomega.8b01034

Table 1. Effect of Compound 18, MA, and OA on the Cell Cycle of T-84 Cells after 24 h of Induction with 0.5, 1, or 2 Times the Corresponding IC50 Valuea.

treatment times IC50 sub-G1 (%) G0–G1 (%) S (%) G2–M (%)
control   2.2 ± 0.7 46.1 ± 1.4 19.9 ± 2.0 31.8 ± 3.0
compound 18 0.5× 2.2 ± 0.5 46.1 ± 2.5 20.7 ± 5.0 30.9 ± 2.3
1.0× 3.8 ± 0.4 67.6 ± 1.6* 5.6 ± 1.9* 23.0 ± 0.4*
2.0× 5.1 ± 0.2* 67.2 ± 1.3* 4.4 ± 1.2* 23.3 ± 0.7*
MA 0.5× 2.3 ± 0.1 61.8 ± 3.2* 13.2 ± 1.0* 22.6 ± 2.1*
1.0× 4.3 ± 0.7* 73.6 ± 2.2* 7.1 ± 1.9* 15.0 ± 0.9*
2.0× 12.6 ± 1.2* 55.4 ± 1.3* 6.3 ± 1.9* 25.6 ± 2.3*
OA 0.5× 3.1 ± 1.0 68.7 ± 2.9* 11.1 ± 2.0* 17.1 ± 0.5*
1.0× 19.0 ± 0.7* 54.5 ± 0.4* 3.1 ± 0.6* 23.4 ± 0.9*
2.0× 45.8 ± 0.9* 40.9 ± 5.2 8.1 ± 4.4* 5.2 ± 1.6*
a

Data are mean ± standard error of the mean of three independent determinations. Symbol * denotes a significant difference with the control group, p < 0.05.