Table 1. Effect of Compound 18, MA, and OA on the Cell Cycle of T-84 Cells after 24 h of Induction with 0.5, 1, or 2 Times the Corresponding IC50 Valuea.
treatment | times IC50 | sub-G1 (%) | G0–G1 (%) | S (%) | G2–M (%) |
---|---|---|---|---|---|
control | 2.2 ± 0.7 | 46.1 ± 1.4 | 19.9 ± 2.0 | 31.8 ± 3.0 | |
compound 18 | 0.5× | 2.2 ± 0.5 | 46.1 ± 2.5 | 20.7 ± 5.0 | 30.9 ± 2.3 |
1.0× | 3.8 ± 0.4 | 67.6 ± 1.6* | 5.6 ± 1.9* | 23.0 ± 0.4* | |
2.0× | 5.1 ± 0.2* | 67.2 ± 1.3* | 4.4 ± 1.2* | 23.3 ± 0.7* | |
MA | 0.5× | 2.3 ± 0.1 | 61.8 ± 3.2* | 13.2 ± 1.0* | 22.6 ± 2.1* |
1.0× | 4.3 ± 0.7* | 73.6 ± 2.2* | 7.1 ± 1.9* | 15.0 ± 0.9* | |
2.0× | 12.6 ± 1.2* | 55.4 ± 1.3* | 6.3 ± 1.9* | 25.6 ± 2.3* | |
OA | 0.5× | 3.1 ± 1.0 | 68.7 ± 2.9* | 11.1 ± 2.0* | 17.1 ± 0.5* |
1.0× | 19.0 ± 0.7* | 54.5 ± 0.4* | 3.1 ± 0.6* | 23.4 ± 0.9* | |
2.0× | 45.8 ± 0.9* | 40.9 ± 5.2 | 8.1 ± 4.4* | 5.2 ± 1.6* |
Data are mean ± standard error of the mean of three independent determinations. Symbol * denotes a significant difference with the control group, p < 0.05.