Table 1. The 11 Male-Specific Loci Associated With Longevity and Replicated in North and South Data Setsa.
| Loci | Chromosome | Nearby Gene | North and South Discovery-Evaluation Analysis of Male-Specific Loci | Female Data Set (North and South Combined) |
P Value of Loci-Sex Interaction Effectsc |
Regression Adjusted for Sex as a Covariate Without Loci-Sex Interaction Term, Using Combined Data Set | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Northb | South | Combined North and South | ||||||||||||||
| P Value | OR (95% CI) |
P Value | OR (95% CI) |
MAF (Case vs Control) | P Value | FDR | OR (95% CI) | MAF (Case vs Control) | P Value | OR (95% CI) | P Value | OR (95% CI) | ||||
| rs1950902 | 14 | MTHFD1 | 5.0 × 10-4 | 1.515 (1.23-1.90) | 1.4 × 10-4 | 1.649 (1.24-2.20) | 0.37 vs 0.26 | 1.1 × 10-7 | 1.4 × 10-6 | 1.595 (1.34-1.90) | 0.32 vs 0.31 | .95 | 1.004 (0.90-1.12) | 8.4 × 10-6 | 3.6 × 10-3 | 1.145 (1.05-1.26) |
| rs1157755 | 12 | KCNA5 | 3.0 × 10-4 | 2.565 (1.28-3.29) | 1.3 × 10-3 | 2.446 (1.88-7.15) | 0.08 vs 0.03 | 1.9 × 10-6 | 7.9 × 10-6 | 2.468 (1.70-3.58) | 0.06 vs 0.06 | .38 | 0.907 (0.73-1.13) | 5.5 × 10-6 | 6.9 × 10-2 | 1.188 (0.98-1.42) |
| rs11136774 | 8 | CSMD1 | 1.8 × 10-4 | 1.600 (1.17-1.88) | 7.6 × 10-3 | 1.475 (1.14-2.13) | 0.30 vs 0.21 | 2.6 × 10-6 | 8.0 × 10-6 | 1.560 (1.30-1.88) | 0.25 vs 0.25 | .85 | 0.988 (0.88-1.11) | 5.0 × 10-5 | 1.6 × 10-2 | 1.131 (1.02-1.25) |
| rs6453914 | 6 | IMPG1 | 9.1 × 10-4 | 1.581 (1.23-2.07) | 2.9 × 10-3 | 1.633 (1.11-2.26) | 0.23 vs 0.16 | 4.1 × 10-6 | 9.7 × 10-6 | 1.624 (1.32-2.00) | 0.19 vs 0.18 | .40 | 1.057 (0.93-1.20) | 5.7 × 10-4 | 1.6 × 10-3 | 1.192 (1.07-1.33) |
| rs6740706 | 2 | LRRFIP1 | 9.4 × 10-7 | 0.536 (0.48-0.77) | 3.9 × 10-2 | 0.734 (0.47-0.90) | 0.20 vs 0.29 | 2.3 × 10-7 | 1.2 × 10-5 | 0.610 (0.51-0.74) | 0.23 vs 0.25 | .39 | 0.950 (0.85-1.07) | 2.9 × 10-4 | 3.6 × 10-4 | 0.837 (0.76-0.92) |
| rs12199884 | 6 | PKHD1 | 9.8 × 10-4 | 0.365 (0.20-0.60) | 9.5 × 10-4 | 0.464 (0.29-0.79) | 0.04 vs 0.08 | 4.1 × 10-6 | 8.1 × 10-6 | 0.428 (0.30-0.61) | 0.06 vs 0.06 | .94 | 0.992 (0.80-1.24) | 9.8 × 10-5 | 4.2 × 10-3 | 0.767 (0.65-0.93) |
| rs79072042 | 5 | NUDT12 | 3.7 × 10-5 | 0.470 (0.38-0.74) | 4.9 × 10-2 | 0.678 (0.39-0.93) | 0.09 vs 0.15 | 7.2 × 10-6 | 1.5 × 10-6 | 0.552 (0.43-0.72) | 0.13 vs 0.13 | .60 | 0.961 (0.83-1.12) | 8.3 × 10-5 | 5.8 × 10-3 | 0.837 (0.73-0.94) |
| rs200536623 | 1 | SYDE2 | 7.4 × 10-5 | 5.917 (2.29-12.06) | 1.5 × 10-2 | 3.553 (1.22-11.6) | 0.04 vs 0.01 | 8.8 × 10-6 | 1.2 × 10-5 | 4.527 (2.33-8.81) | 0.02 vs 0.02 | .54 | 1.136 (0.75-1.71) | 5.5 × 10-4 | 1.8 × 10-3 | 1.726 (1.25-2.48) |
| rs138863 | 22 | BRD1 | 6.9 × 10-3 | 0.270 (0.11-0.66) | 5.4 × 10-4 | 0.200 (0.07-0.50) | 0.01 vs 0.04 | 9.5 × 10-6 | 1.1 × 10-5 | 0.220 (0.12-0.44) | 0.02 vs 0.03 | .17 | 0.790 (0.57-1.10) | 8.5 × 10-4 | 1.3 × 10-4 | 0.575 (0.44-0.77) |
| rs9894443 | 17 | SLC39A11 | 2.6 × 10-3 | 1.390 (1.13-1.70) | 6.3 × 10-4 | 1.560 (1.25-2.19) | 0.42 vs 0.34 | 8.2 × 10-6 | 1.2 × 10-5 | 1.450 (1.23-1.70) | 0.35 vs 0.37 | .41 | 0.960 (0.86-1.06) | 2.6 × 10-5 | 8.8 × 10-2 | 1.078 (0.99-1.18) |
| rs73329622 | 5 | STK10 | 3.3 × 10-3 | 0.680 (0.57-0.93) | 9.5 × 10-4 | 0.600 (0.39-0.75) | 0.18 vs 0.26 | 9.2 × 10-6 | 1.0 × 10-5 | 0.640 (0.53-0.78) | 0.22 vs 0.22 | .88 | 0.990 (0.88-1.12) | 2.4 × 10-4 | 9.1 × 10-3 | 0.872 (0.78-0.96) |
Abbreviations: FDR: false discovery rate; MAF, minor allele frequency; OR, odds ratio.
As discussed in eAppendix section S2 in the Supplement, the ORs in this and other Tables cannot be interpreted as the size of pure effects of the genotype on longevity because they are estimated based on the differences of the proportions of carrying the genotype between the cases (centenarians) and controls (middle-aged adults) and these proportions also depend on other factors, such as gene-environment interaction effects.
The sex-specific subsample sizes of north, south, and north-south combined regions are listed in eTable 1 in the Supplement.
The estimates of P value of loci-sex interaction effects are based on logistic regressions including the loci, sex, and loci-sex interaction term, using the north-south combined data set.