Table 4. Polygenic Risk Score Analyses on the Joint Effects of Sex-Specific Loci’s Association With Longevity.
| Analysis | Main Effect of PRS in Men | Main Effect of PRS in Women | OR (95% CI) of PRS-Sex Interaction | P Value of PRS-Sex Interaction | Pseudo R2 | |||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) |
P Value |
OR (95% CI) |
P Value |
Men | Women | |||
| A. Analyses using north data set as discovery sample and south data set as target samplea | ||||||||
| A1. 11 Male and 11 female loci with P < 10-5b | ||||||||
| 11 Loci with P < 10-5 in men but P > .05 in women | 2.136 (1.73-2.64) | 4.0 × 10-12 | 1.040 (0.93-1.16) | .48 | 2.054 (1.62-2.61) | 0.487 (0.38-0.62) | 4.1 × 10-9 | 0.025 |
| 11 Loci with P < 10-5 in women but P > .05 in men | 0.886 (0.75-1.05) | .15 | 1.782 (1.58-2.01) | 4.1 × 10-21 | 0.497 (0.41-0.61) | 2.011 (1.64-2.46) | 2.2 × 10-11 | 0.040 |
| A2. 35 Male and 25 female loci with 10-5 ≤ P < 10-4c | ||||||||
| 35 Male-specific loci with 10-5 ≤ P < 10-4 in men but P > .25 in women | 3.618 (2.86-4.58) | 1.8 × 10-26 | 1.005 (0.90-1.12) | .92 | 3.599 (2.77-4.68) | 0.278 (0.21-0.36) | 8.5 × 10-22 | 0.066 |
| 25 Female-specific loci with 10-5 ≤ P < 10-4 in women but P > .35 in men | 0.920 (0.78-1.09) | .33 | 2.229 (1.96-2.54) | 2.5 × 10-34 | 0.413 (0.33-0.51) | 2.423 (1.96-2.99) | 2.2 × 10-16 | 0.069 |
| B. Analyses using south data set as discovery sample and north data set as target sample | ||||||||
| B1. 11 Male and 11 female loci with P < 10-5 | ||||||||
| 11 Loci with P < 10-5 in men but P > .05 in women | 2.473 (2.06-2.97) | 7.2 × 10-22 | 0.935 (0.85-1.03) | .17 | 2.644 (2.15-3.25) | 0.378 (0.31-0.46) | 5.6 × 10-20 | 0.044 |
| 11 Loci with P < 10-5 in women but P > .05 in men | 0.976 (0.84-1.14) | .76 | 1.626 (1.47-1.80) | 1.3 × 10-20 | 0.601 (0.50-0.72) | 1.665 (1.38-2.00) | 6.5 × 10-8 | 0.037 |
| B2. 35 Male and 25 female loci with 10-5 ≤ P < 10-4 | ||||||||
| 35 Male-specific loci with 10-5 ≤ P < 10-4 in men but P > .25 in women | 3.509 (2.87-4.29) | 4.2 × 10-34 | 0.956 (0.87-1.05) | .36 | 3.671 (2.93-4.59) | 0.272 (0.22-0.34) | 7.2 × 10-30 | 0.072 |
| 25 Female-specific loci with 10-5 ≤ P < 10-4 in women but P > .35 in men | 0.872 (0.75-1.01) | .07 | 2.014 (1.80-2.25) | 5.4 × 10-35 | 0.433 (0.36-0.52) | 2.31 (1.92-2.78) | 6.3 × 10-19 | 0.062 |
| C. Analyses using north and south combined data set | ||||||||
| C1. 11 Male and 11 female loci with P < 10-5 | ||||||||
| 11 Loci with P < 10-5 in men but P > .05 in women | 2.579 (2.24-2.97) | 1.3 × 10-39 | 1.061 (0.99-1.14) | .11 | 2.431 (2.08-2.84) | 0.411 (0.35-0.48) | 1.0 × 10-27 | 0.043 |
| 11 Loci with P < 10-5 in women but P > .05 in men | 0.978 (0.88-1.09) | .70 | 1.741 (1.61-1.88) | 2.8 × 10-42 | 0.562 (0.49-0.64) | 1.779 (1.55-2.04) | 1.2 × 10-16 | 0.040 |
| C2. 35 Male and 25 female loci with 10-5 ≤ P < 10-4 | ||||||||
| 35 Male-specific loci with 10-5 ≤ P < 10-4 in men but P > .25 in women | 3.996 (3.40-4.69) | 1.5 × 10-64 | 1.048 (0.97-1.13) | .21 | 3.812 (3.20-4.55) | 0.262 (0.22-0.31) | 4.8 × 10-50 | 0.079 |
| 25 Female-specific loci with 10-5 ≤ P < 10-4 in women but P > .35 in men | 0.934 (0.84-1.04) | .22 | 2.141 (1.97-2.33) | 2.8 × 10-70 | 0.436 (0.38-0.50) | 2.293 (2.00-2.63) | 4.3 × 10-32 | 0.066 |
Abbreviations: OR, odds ratio; PRS, polygenic risk score.
a
In analyses presented in sections A and B, we used the ORs of the sex-specific loci estimated based on the discovery sample of north (or south) data set as weights to construct the PRS scores in the target sample of south (or north) data set, following the standard procedure applied in the literature.20
b
The detailed information of the 11 male-specific and 11 female-specific longevity loci with P < 10−5 are presented in Tables 1 and 2.
c
The detailed information of the 35 male-specific and 25 female-specific loci with 10−5 ≤ P < 10−4 are presented in eTables 4 and 5 in the Supplement.