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. 2018 Sep 26;3(9):12010–12018. doi: 10.1021/acsomega.8b01558

Figure 1.

Figure 1

Concept of the construction of electrochemical aptasensor for the sensing of cardiovascular biomarkers BNP and cTnI: (A) formation of the interface: (I) electrophoretic deposition (EPD) of a solution of GO/PEI on gold SPE forming a rGO/PEI thin film and (II) amide bond formation between the acid groups of propargylacetic acid and NH2 groups of PEI by EDC/NHS chemistry; (B) integration of aptamers (III) using Cu(I)-catalyzed click chemistry to N3-modified DNA aptamer and (IV) passivation with synthetic pyrene-PEG (green layer).