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. 2018 Jun 13;218(10):1663–1674. doi: 10.1093/infdis/jiy347

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Figure 6. — Model of eicosanoid-coordinated neutrophil migration across Neisseria gonorrhoeae (GC)–infected endocervical cells. GC infection stimulates human End1/E6E7 (End1) protein kinase C, phospholipase A₂, and lipoxygenases (LOXs) 12R-LOX and eLOX-3 to produce the eicosanoid hepoxilin A₃ that is directed apically through the MRP2 channel. Transmigrating neutrophils activate 5-LOX to produce leukotriene B₄ that acts in paracrine and autocrine fashion to amplify neutrophil influx. Abbreviations: 5-LOX, 5-lipoxygenase; 12R-LOX, arachidonate 12-lipoxygenase; eLOX-3, epidermis-type lipoxygenase 3; HXA₃, hepoxilin A₃; LTB₄, leukotriene B₄; PKC, protein kinase C; PLA₂, phospholipase A₂.