Table 1.
Details of Patient Samples Sequenced in This Study
| Identity | Age | Source Country | Sample Type | Immune Status | Note | Diversity | Number of Variant Alleles |
|---|---|---|---|---|---|---|---|
| VES1 | 55 (Patient A) | UK | Vesicle | Immunocompromised | Varicella | 4.20E-05 | 2 |
| BAL1 | BAL | 1.58E-04 | 33 | ||||
| PLAS1 | Plasma | 4.90E-05 | 5 | ||||
| VES2 | 67 (Patient B) | UK | Vesicle | Immunocompromised | Zoster (disseminated) | 3.97E-05 | 8 |
| SPU | Sputum | 3.28E-05 | 6 | ||||
| PLAS2 | Plasma | 8.02E-04 | 103 | ||||
| CSF3 | 76 (Patient C) | UK | CSF | Immunocompetent | Encephalitis with Zoster | 9.75E-05 | 23 |
| VES27 | Vesicle | 4.39E-05 | 1 | ||||
| VES18 | 2 (Patient D) | UK | Vesicle | Immunocompetent | Varicella | 7.75E-08 | 9 |
| VES19 | Vesicle | 1.60E-05 | 17 | ||||
| VES20 | Vesicle | 4.83E-06 | 2 | ||||
| VES21 | Vesicle | 3.34E-05 | 2 | ||||
| VES22 | Vesicle | 2.58E-05 | 0 | ||||
| VES4 | 8 (Patient E) | UK | Vesicle | Immunocompetent | Varicella | 3.70E-05 | 2 |
| VES26 | 3.37E-05 | 0 | |||||
| VES6 | 3 (Patient F) | UK | Vesicle | Immunocompetent | Varicella | 5.81E-06 | 25 |
| VES25 | 5.14E-05 | 0 | |||||
| PLAS3 | 8 | UK | Plasma | Immunocompromised | Zoster | 2.83E-06 | 16 |
| BAL2 | 10 | UK | BAL | Immunocompetent | Zoster | 4.45E-05 | 25 |
| CSF1 | 42 | UK | CSF | Immunocompetent | Encephalitis | 4.58E-04 | 133 |
| CSF2 | 32 | UK | CSF | Immunocompetent | Encephalitis | 2.38E-04 | 169 |
| CSF4 | 81 | Sweden | CSF | Immunocompetent | Encephalitis | 3.42E-05 | 21 |
| CSF5 | 70 | Sweden | CSF | Immunocompetent | Encephalitis | 6.24E-05 | 31 |
| CSF6 | 58 | Sweden | CSF | Immunocompetent | Encephalitis | 8.35E-05 | 14 |
| CSF7 | 54 | Singapore | CSF | Immunocompetent | Encephalitis + Zoster | 3.30E-05 | 85 |
| CSF8 (UKM1018a) | 28 | UK | CSF | Immunocompetent | Meningitis | 2.81E-05 | 11 |
| CSF9 (UKM1211a) | 29 | UK | CSF | Immunocompromised | Meningitis | 6.03E-05 | 5 |
| CSF10 (UKM0338a) | 22 | UK | CSF | Immunocompetent | Meningitis | 2.23E-06 | 6 |
| CSF11 (UKM0624a) | 69 | UK | CSF | Immunocompetent | Meningitis | 3.41E-05 | 2 |
| CSF12 | 74 | UK | CSF | Immunocompetent | Encephalitis | 1.00E-04 | 0 |
| VES3 | 61 | UK | Vesicle | Immunocompromised | Zoster | 5.64E-05 | 8 |
| VES5 | 8 | UK | Vesicle | Immunocompromised | Varicella | 3.17E-05 | 1 |
| VES7 | 62 | Sweden | Vesicle | Immunocompetent | Zoster | 1.34E-05 | 2 |
| VES8 | 74 | Sweden | Vesicle | Immunocompetent | Zoster | 2.21E-05 | 3 |
| VES9 | 69 | Sweden | Vesicle | Immunocompetent | Zoster | 1.52E-05 | 42 |
| VES10 | 89 | Sweden | Vesicle | Immunocompetent | Zoster | 3.31E-05 | 6 |
| VES11 | 76 | Sweden | Vesicle | Immunocompromised | Zoster | 2.43E-05 | 4 |
| VES12 | 90 | Sweden | Vesicle | Immunocompetent | Zoster | 2.27E-05 | 2 |
| VES13 | 80 | Sweden | Vesicle | Immunocompetent | Zoster | 4.79E-05 | 3 |
| VES14 | 79 | Sweden | Vesicle | Immunocompetent | Zoster | 1.53E-05 | 3 |
| VES15 | 83 | Sweden | Vesicle | Immunocompetent | Zoster | 4.70E-05 | 4 |
| VES16 | 44 | Singapore | Vesicle | Immunocompetent | Varicella | 1.96E-05 | 3 |
| VES17 | 4 | Germany | Vesicle | Immunocompetent | Varicella | 4.14E-05 | 6 |
| VES23 | 10 | Italy | Vesicle | Immunocompetent | Varicella | 2.00E-05 | 0 |
| VES24 | 66 | Sweden | Vesicle | Immunocompetent | Zoster | 1.22E-05 | 0 |
Abbreviations: BAL, bronchoalveolar lavage; CSF, cerebrospinal fluid; PLAS, plasma; SPU, sputum; VES, vesicle.
aUK Meningitis Study.