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. Author manuscript; available in PMC: 2019 Oct 4.
Published in final edited form as: Mol Cell. 2018 Sep 20;72(1):162–177.e7. doi: 10.1016/j.molcel.2018.08.015

Figure 6. Highly-specific anti-H3K4me1 ICeChIP-seq can reveal differences between MLL3/4 WT and /catalytically dead cell lines.

Figure 6.

(A) Specificity of H3K4me1 ICeChIP-seq in WT and dCD MLL3/4 R1 mESCs. (B) Global H3K4me1 abundances, as proportion of nucleosomes (left) and globally integrated HMD (right). (C) A representative genome browser view of H3K4me1 HMD in WT and dCD MLL3/4 R1 mESCs near an enhancer (Dorighi et al., 2017). (D) Heatmap of H3K4me1 HMD about enhancers in WT and dCD MLL3/4 R1 mESCs, sorted by MLL3/4 ChIP-seq signal (Dorighi et al., 2017).