Table 1.

Demographic characteristics for the overall cohort (n=48,158).

	Overall 2003–2015 n = 48,158	Era 1 2003–2010 n = 30,028	Era 2 2011–2013 n = 11,361	Era 3 2014–2015 n = 6,769	p*
Age (IQR)	55 (49–60)	54 (48–59)	56(50–61)	56 (50–62)	<0.001
Male (%)	61.9	61.9	62.3	60.1	0.19
Race (%)
Caucasian non-Hispanic	73.6	73.8	73.4	73.0	<0.001
Hispanic/Latino	16.0	16.1	16.1	15.3
African American	6.6	6.4	6.7	7.4
Asian	3.0	3.0	2.8	3.1
Other/Missing	0.8	0.7	1.0	1.2
Etiology (%)
HCV	41.6	45.8	38.6	27.9	<0.001
NASH/CC/EtOH	40.4	35.9	44.1	54.2
HBV	2.5	2.8	1.9	2.0
Autoimmune†	14.2	14.2	13.9	14.4
Other¶	1.3	1.3	1.5	1.5
Diabetes (%)	26.8	25.7	27.7	30.0	<0.001
CTP score (%)
5–6	13.4	13.5	13.3	13.2	<0.001
7–9	40.9	40.3	39.5	46.4
10–15	45.6	46.2	47.2	40.5
Median follow-up time, days (IQR)	493 (189–1083)	600 (206–1358)	482 (176–1013)	305 (156–515)	<0.001
De novo HCC (%)	6.5	7.5	5.7	3.1	<0.001

^*comparing Era 1 vs. 2 vs. 3

^†includes autoimmune hepatitis, PSC, PBC

^¶includes hemochromatosis, A1AT and Wilson