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. 2018 Oct 5;8:14853. doi: 10.1038/s41598-018-33135-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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KIR2DL2 allele typing method. (A) Alignment of the amino acid sequences of the 13 known KIR2DL2 allelic variants. A dash indicates identity with the consensus KIR2DL2*003. Structural domains are indicated: Ig-like domains (D1 and D2), stem domain (ST), transmembrane domain (TM), and cytoplasmic domain (CYT). Four PCR reactions separate the three subgroups identified by phylogenetic analysis. Two additional PCR reactions separate alleles within subgroups. Frequencies of the alleles present in the learning cohort of 426 individuals and in the testing cohort of 260 individuals are indicated. The group identification of each allele is indicated. The alleles tested by PCR are in bold black font, and non-tested alleles are in gray italics. (B) KIR2DL2 PCR interpretation guide. PCR profiles marked by *, #, $ or & are similar and require a higher resolution of genotyping using supplemental reactions.