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. 2018 Oct 5;8:14888. doi: 10.1038/s41598-018-33134-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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FLIM representation at 890 nm for each tissue type. (a–c) FLIM images of control sample (a), metastasis sample (b), and GBM (c). Scale bars of 100 μm, (d–f) give the color scale of FLIM imaging with the histogram of the average lifetime; shorter lifetimes (blue) are on the left side of the color scale, and longer lifetime (red) on the right side, two measurements were taken and the full width at half maximum of distribution and the average lifetime of the maximum. SHG is not a fluorescent but diffusing process, appearing as very short lifetime corresponding to the instrument response function (IRF), which is of the order of 0.06 ns and shown in blue in the FLIM images. The typical vascular structures of each tissue are consequently as recognizable as in the TPEF images.