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. 2018 Oct 5;8:209. doi: 10.1038/s41398-018-0265-9

Fig. 1. A single 10 min exposure to TMT results in three distinct anxiety phenotypes 1 week later.

Fig. 1

a Timeline of experimental procedures. b Time spent in the open arms of the EPM is plotted against startle behavior, expressed as the % habituation of initial ASR for rats exposed to TMT. A median split on both time spent in the open arms (median = 56 s) and ASR (median = 82.7% initial ASR) was used to separate TMT-exposed rats into susceptible, resilient and intermediate phenotypes. c Control rats did not receive TMT exposure; using the median split criteria (e.g. a cutoff of 56 s for open arm entries), only one rat was classified as stress-susceptible susceptible while 67% were classified as resilient. Comparing all TMT-exposed rats (n = 119) to control rats (n = 30) there was an effect of TMT on time spent in the open arms (d) and ASR habituation e. Upon application of the median split criteria, there were phenotypic differences in mean time spent in the open arms of the EPM (f) and ASR habituation g. For (f) and g, n = 30 for control, n = 26 each for susceptible and resilient. *p < 0.05 compared to control; #p < 0.05 compared to resilient. Data are presented as mean ± SEM