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. 2018 Oct 5;8:14872. doi: 10.1038/s41598-018-33293-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of High glucose and empagliflozin on the functional alterations of cardiomyocytes derived from IMR90 hiPSCs. (A) Representative immunofluorescence staining, and (B) cell size of IMR90 hiPSC-derived cardiomyocytes cultured in normal glucose (5.5 mM); high glucose (22 mM); high glucose and empagliflozin; and high glucose for 7 days followed by empagliflozin (Red: α-Actinin; blue: DAPI). (C) Existence of SGLT1 and SGLT2 transcripts in the IMR90 hiPSC-derived cardiomyocytes were evaluated by PCR analysis. (D,E) Real-time quantitative PCR analysis of SGLT1 and SGLT2 expression. (F) % of cell shortening. (G) Amplitude of intracellular calcium trainsets. *p < 0.05; **P < 0.01.