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. 2018 Oct 5;8:14890. doi: 10.1038/s41598-018-33232-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Experimental Study Design. (Part A): 12-week-old, female BALB/c mice were subjected to either TSH (femur fracture/splenectomy/hemorrhagic shock) or TH (femur fracture/hemorrhagic shock) followed by CLP (cecal ligation and puncture) to induce secondary sepsis 48 h later, or to CLP alone. 20 µl of blood, indicated by small blood drops, were collected at 6 h and 24 h post-CLP and survival was observed for 28 days. (Part B): 12 week old, female BALB/c mice were subjected to either TSH (unilateral femur fracture/splenectomy/hemorrhagic shock) or TH (unilateral femur fracture/hemorrhagic shock). Terminal blood, indicated by large blood drops, was collected either 24 h or 48 h post trauma.