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. 2018 Oct 5;8:14881. doi: 10.1038/s41598-018-32925-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Alpha and Beta diversity. (A–D) Alpha diversity measures. Box plots of (A) observed OTUs, (B) Shannon index, (C) Dominance, and (E) Equitability calculated for mice groups at T0 = before the treatment, after 11 days of OEA treatment (OEA_T11) and after 11 days of vehicle treatment (Vehicle_ T11). Pairwise comparisons by using the Wilcoxon rank sum test were not significant. (E-F) Beta diversity measure. (E) PCoA, and (F) NMDS based on Bray Curtis dissimilarities. Samples at T0, samples of OEA_T11 and Vehicle_T11 are indicated with different colours. P = 0.035 PERMANOVA using the Adonis function with 999 permutations. For NMDS, stress value=0.09 indicated a good representation.