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. 2018 Oct 5;8:14886. doi: 10.1038/s41598-018-33151-1

Figure 7.

Figure 7

Mitochondrial OGG1 overexpression attenuates diet-induced weight gain in Ogg1−/− mice. Ogg1Tg mice were crossed with Ogg1−/− mice (n = 6) and either maintained on chow diet or transitioned to a high-fat diet (HFD) at 8 weeks of age. Chow-fed mice were weighed (a) and body composition was determined (b) at the indicated intervals. HFD-induced weight gain (c) was determined weekly, and body composition was measured by NMR (d) before and 6 weeks after the start of HFD-feeding. *p < 0.05 vs. WT and Ogg1−/−.