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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: J Biol Inorg Chem. 2018 Mar 5;23(3):399–411. doi: 10.1007/s00775-018-1546-8

Figure 5.

Figure 5.

Inhibition of prometastatic protumorigenic factors in in Caki-1 renal cancer cells A. Inhibition of mitochondrial protein TrxR by bimetallic Ru-Au compound RANCE-1 (1), the monometallic ruthenium R (2) and gold ANCE-1 (3) compounds and Auranofin (1 μM) for 72 hours. The values for indicate the percentage of reduction of TrxR activity relative to 0.1% DMSO treated control. B. Inhibition of pro-angiogenic proteins VEGF by bimetallic Ru-Au compound RANCE-1 (1), the monometallic ruthenium R (2) and gold ANCE-1 (3) compounds and Auranofin (IC 20 concentrations) for 24 hours. The values for indicate the absolute concentration (pg/ml) of VEGF following treatment, 0.1% DMSO control. C. RANCE-1 (1) and Auranofin induced changes in the expression levels of Interleukins. Analysis of 150ng of protein extracted from cell lysate collected from RANCE-1 or Auranofin (IC20) treated cells. All the data shown are representative of triplicates.