Skip to main content
. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: J Biol Inorg Chem. 2018 Mar 5;23(3):399–411. doi: 10.1007/s00775-018-1546-8

Table 1.

Cell viability IC50 values (μM) in Caki-1 cells and IMR-90 fibroblasts for bimetallic RANCE-1 (1) and monometallic Ru R (2) Au ANCE-1 (3) compounds. Auranofin and cisplatin were used as controls.a The values are also plotted in a bar graph for a better visualization of the selectivity profiles.
Caki-1 IMR90 graphic file with name nihms-990448-t0010.jpg
RANCE-1 (1) 8.7 ± 0.9 17.3 ± 0.8
R (2) 27.8 ± 2.9 35.9 ± 2.3
ANCE-1 (3) 19.8 ± 1.6 37.6 ± 2.1
R (2) + ANCE-1 (3) 16.6 ± 1.3 28.1± 3.4
Auranofin 2.8 ± 0.6 3.7 ± 0.4
Cisplatin 23.9 ± 2.4 3.9 ± 0.5
a

All compounds were dissolved in 1% of DMSO and diluted with media before addition to cell culture medium for a 72 hour incubation period. Cisplatin was dissolved in H2O·