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. 2018 Oct 5;23:49. doi: 10.1186/s11658-018-0113-1

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Evaluation of the effect of bFGF administration on cartilage proliferation. a. Concentration-dependent effect of bFGF on auricular chondrogenesis. The box plot shows the cartilage neogenesis rate for different concentrations of bFGF. Kruskal-Wallis analysis revealed a highly significant difference among the groups (P < 0.0001). Post hoc comparisons by the Fisher test indicated significant differences between the groups injected with more than 5 μg/ml and the control group, but the difference between animals injected with 1 μg/ml bFGF and the control group was not statistically significant. b. Blocking of bFGF stimulation using an anti-bFGF neutralizing antibody. The box plot shows the cartilage neogenesis rate immediately after injection of bFGF, immediately after and 1 week after injection of bFGF, immediately after and 2 weeks after injection of bFGF, 1 week after injection of bFGF, 2 weeks after injection of bFGF, and the control. Kruskal Wallis analysis revealed a significant difference between the three groups immediately after injection of bFGF and the control group (P < 0.01), but suppression of chondrogenesis at 1 week and 2 weeks after bFGF injection was not recognized in comparison with the control group. **P < 0.01. “Reprinted with permission from (Koizumi, N. (2010). Basic fibroblast growth factor stimulates proliferation and differentiation of perichondrocytes of rabbit auricular cartilage in vivo. Journal of Kanazawa Medical University, 35, 122–130.). Copyright (2010) publication administration of Kanazawa Medical University”