Fig. 3.

CFP1 binding in TSSs is predictive of expression from accessible TSSs. Upper panels (a, c, d, g, h, k, l) represent data in Erythroblasts (ERY) and lower panels (b, e, f, i, j, m, n) represent EBV-lymphoblasts (EBV). a, b Heatmap analysis of CFP1 binding. TSSs are divided into CGI and non-CGI subsets, and then ordered by expression RPKM values. CFP1 and Pol II are measured as read depth normalised to 1x genome-wide, and input-subtracted. c–f Gene expression level plotted against normalised CFP1 signal (thresholded and log-transformed). Gene expression measure is log₂ RPKM of all transcripts of the gene combined. c, e CGI TSSs and d, f non-CGI TSSs. g–j Gene expression level plotted against normalised Pol II signal. g, i CGI TSSs and h, j non-CGI TSSs. k–n Pol II signal plotted against CFP1 signal: k, m CGI TSSs and l, n non-CGI TSSs