Table 2.
Pain and sedation scores and physiological parameters in dogs undergoing ovariohysterectomy
| Time points | Drugs | CMPS-SF | DIVAS | Temperature (°C) | HR (bpm) | RR (bpm) | SAP (mmHg) | MAP (mmHg) | DAP (mmHg) | SpO2 (%) |
|---|---|---|---|---|---|---|---|---|---|---|
| Time 0 (baseline values) | VG | 0 (0) | 0 (0) | 38.5 (38.2–38.8) | 125 (107–143) | 37 (30–44) | 159 (141–177) | 116 (104–127) | 91 (79–102) | 97 (96–98) |
| SG | 0 (0) | 0 (0) | 38.5 (37.9–39.0) | 117 (105–129) | 37 (30–44) | 167 (145–188) | 123 (111–134) | 100 (89–110) | 96 (95–98) | |
| 15 min after premedication | VG | 22.3 (18.4–26.3) | 38.2 (38.1–38.3)a | 94 (80–108)a | 34 (28–40) | 146 (125–166) | 100 (89–111)a | 75 (67–84a | 98 (97–99) | |
| SG | 23.7 (13.4–33.9) | 38.1 (37.9–38.3)a | 100 (86–115) | 34 (27–40) | 140 (133–146)a | 97 (90–104)a | 77 (70–83) a | 96 (95–97) | ||
| Postoperative 0.5 h | VG | 1.25 (0.6–1.9) | 38.9 (28.1–49.7) | 37.0 (36.7–37.4)a | 102 (84–120)a | 34 (30–38) | 157 (143–172) | 117 (104–130) | 95 (84–106) | 97 (96–97) |
| SG | 0.92 (0.4–1.4) | 38.1 (24.2–52) | 36.8 (36.5–37.1)a | 109 (98–121) | 29 (24–34) | 161 (153–170) | 118 (113–124) | 95 (89–101) | 97 (96–97) | |
| Postoperative 1 h | VG | 1.5 (0.4–2.6) | 27.8 (16,5–39) | 37.1 (36.8–37.5)a | 94 (76–112)a | 31 (25–37) | 158 (145–172) | 114 (102–126) | 87 (79–96) | 97 (96–98) |
| SG | 1 (0.6–1.4) | 32.7 (19.9–45.5) | 37 (36.7–37.3)a | 105 (94–116) | 31 (27–36) | 153 (141–164)a | 115 (109–122) | 93 (87–99) | 96 (95–97) | |
| Postoperative 2 h | VG | 1.27 (−0.1–2.7) | 18.9 (15.5–22.4) | 37.2 (36.9–37.6)a | 91(75-108)a | 29 (24–35) | 151 (136–165) | 105 (95–115) | 83 (74–92) | 97 (96–99) |
| SG | 0.5 (0.1–0.9) | 22 (16.3–27.4) | 37.2 (36.9–37.5)a | 103 (89–118) | 31 (27–35) | 161 (153–169) | 115 (109–121) | 90 (82–99) | 96 (95–97) | |
| Postoperative 3 h | VG | 1 (−0.3–2.3) | 13.9 (11.3–16.5) | 37.4 (37.1–37.6)a | 92 (68–116)a | 31 (26–35) | 157 (143–170) | 108 (100–116) | 82 (76–88) | 97 (96–98) |
| SG | 0.7 (0.3–1.1) | 15.3 (11.2–19.3) | 37.4 (37.3–37.6) | 88 (79–97)a | 32 (27–36) | 156 (147–166) | 113 (108–119) | 89 (84–95) | 97 (96–98) | |
| Postoperative 4 h | VG | 0.9 (0.3–1.5) | 10.4 (6.5–14.4) | 37.4 (37.2–37.6)a | 86 (66–105)a | 32 (27–37) | 157 (139–176) | 116 (105–127) | 90 (82–98) | 97 (96–99) |
| SG | 0.5 (0.1–0.9) | 12.3 (7.9–16.6) | 37.5 (37.4–37.7)a | 88 (77–99)a | 32 (27–36) | 159 (149–169) | 110 (104–116)a | 85 (79–90)a | 96 (95–97) | |
| Postoperative 6 h | VG | 0.3 (−0.4–1.1) | 6.8 (3.8–9.8) | 37.6 (37.4–37.8)a | 92 (74–109)a | 31 (24–39) | 155 (138–172) | 109 (99–119) | 82 (73–91) | 97 (96–98) |
| SG | 0.2 (−0.1–0.4) | 6.8 (4.4–9.1) | 37.6 (37.4–37.9)a | 96 (85–107)a | 33 (28–37) | 160 (148–171) | 114 (106–122) | 90 (84–96) | 97 (96–97) | |
| Postoperative 8 h | VG | 0.1 (−0.2–0.4) | 4.1 (0.8–7.3) | 37.8 (37.5–38.0)a | 89 (78–100)a | 31 (26–37) | 158 (139–178) | 107 (96–118) | 82 (73–91) | 97 (96–99) |
| SG | 0.1 (−0.1–0.3) | 3.3 (2.1–4.4) | 37.9 (37.7–38.0)a | 101 (87–114) | 33 (29–38) | 159 (146–172) | 110 (110–120)a | 88 (79–96)a | 97 (96–98) |
Mean (CI) for pain scores using the Glasgow Composite Pain Scale short-form (CMPS-SF), sedation scores using the dynamic and interactive visual analogue scale (DIVAS) and physiological parameters including temperature, heart rate (HR), respiratory rate (RR), systolic (SAP), mean (MAP) and diastolic (DAP) blood pressure, and pulse oximetry (SpO2) in dogs undergoing ovariohysterectomy and treated with carprofen in combination with two concentrations of buprenorphine (Vetergesic - VG or Simbadol - SG)
aSignificant difference when compared with baseline values