Table 2.
sEPCR levels and polymorphism (n = 278)
| Global n = 278 |
Non-survivors n = 84 |
Survivors n = 194 |
P value | |
|---|---|---|---|---|
| sEPCR level in plasma (ng/mL) | ||||
| Day 1, n = 278 | 92.0 ± 54.9 | 102.5 ± 57.9 | 87.5 ± 53.0 | 0.0447 |
| Day 2, n = 261 a | 91.3 ± 55.2 | 108.8 ± 63.9 | 84.6 ± 50.1 | 0.0047 |
| Delta EPCR: day 2 - day 1 | −1.3 ± 24.4 | 4.6 ± 26.9 | −3.5 ± 23.1 | 0.0268 |
| EPCR A3 haplotype, n (%) (n = 259b) | 38 (14.7) | 10 (12.8) | 28 (15.5) | 0.5804 |
Description of soluble endothelial protein C receptor (sEPCR) levels at day 1, day 2, kinetics between day 1 and day 2, and polymorphism EPCR A3 in survivors and non-survivors
a17 blood samples were missing at day 2 (9 patients died before day 2, 8 sample were missing)
b19 DNA samples were missing (3 patients died before DNA sample was obtained, and DNA sample was missing for 16 patients)