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. 2018 Oct 5;19:198. doi: 10.1186/s12931-018-0901-1

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Effect of TMX and ATP on current density in CFBE cells. a example of current/voltage relationship of cells in control conditions (squares), in the presence of 10 μM TMX (circles) and after addition of 100 μM ATP (triangles). b example of current/voltage relationship of cells in control conditions (squares), and in the presence of 10 μM TMX + 100 μM ATP (circles). Membrane current stimulated by TMX + ATP was almost totally inhibited by 300 μM NPPB (triangles). c plot of membrane current density expressed as a percentage of increase at + 80 mV relative to the value of the current in control conditions (n = 15; p ≥ 0.001). TMX in combination with ATP (n = 10) produced a significant increment compared with TMX stimulation alone (n = 11; p ≥ 0.05). Addition of NPPB completely inhibited the current (n = 6)