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. 2018 Oct 5;19:198. doi: 10.1186/s12931-018-0901-1

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Effect of ivacaftor (VX-770) and lumacaftor (VX-809) on current density of CFBE cells. a example of current/voltage relationship of cells in control conditions (squares), in the presence of 1 μM VX-770 and 3 μM VX-809 (circles) and after addition of 10 μM forskolin (triangles). Addition of the CFTR ion channel blocker Inh-172 reduced the transmembrane current almost to that occurring in control conditions (diamonds). b chart plot of membrane current density at + 80 mV relative to the value of the current in control conditions (n = 11), stimulated by VX-770 and VX-809 (n = 8) and after the addition of forskolin (n = 8) compared to current inhibitor Inh-172 (n = 4; p ≥ 0.001)