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. Author manuscript; available in PMC: 2019 Jul 7.
Published in final edited form as: J Theor Biol. 2018 Mar 30;448:86–93. doi: 10.1016/j.jtbi.2018.03.036

Fig. 4.

Fig. 4.

Mutant dynamics predicted by the ODE model (2) without feedback on de-differentiation. The number of mutant stem cells initially declines until the differentiated cell population has built up, at which point the populations converge to a neutrally stable equilibrium. Parameters were chosen as follows. r’ = 0.01; p’ = 0.8; α = 0.0025; g = 0.001; h1 = h2 = 0.0001; k1 = k2 = 1.