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. Author manuscript; available in PMC: 2019 Mar 17.
Published in final edited form as: Nature. 2018 Sep 17;561(7724):542–546. doi: 10.1038/s41586-018-0527-y

Extended Data Figure 2 |. Optogenetic manipulations of barrel cortex using PV-ChR and Emx1-Halo result in similar behavioral, motor, and sensory deficits.

Extended Data Figure 2 |

a, Photoinhibition of excitatory neurons in Emx1-Halo (orange) and photoactivation of inhibitory neurons in PV-ChR (blue) yielded similar behavioral deficits. Negative control animals (Cre-negative, stop-Halo mice, black) were unaffected by 593-nm laser illumination. b, Both Emx1-Halo and PV-ChR photostimulation decrease whisking kinematics and c, increase sensory thresholds. Data for negative control and Emx1-Halo are the same as in Figures 2 and 3 but repeated here for comparison with PV-ChR.