a,Position and relative enrichment of ESRP2 binding motifs within exonic and 250nt intronic sequences surrounding the regeneration-regulated exons. b, Heatmap of differences in RT-PCR derived exon inclusion (row-normalized, ΔPSI) values in WT, Esrp2KO and ESRP2 overexpression (OE) livers under CHOW and DDC conditions (n=3). Numeral after gene name signifies the size of alternative exon. c, Genome browser views of RNA-seq data from E18 and adult mouse hepatocytes demonstrating developmental regulation of alternative exons in Hippo pathway genes-Nf2, Csnk1d, Yap1 and Tead1 (n= 2 biological replicates). d, Difference in Percent Spliced Index (ΔPSI) values for Nf2, Csnk1d, Yap1 and Tead1 alternative exons (n=3), and e, Heatmap of relative expression for Hippo target genes (qPCR) in WT, Esrp2KO and ESRP2 OE livers under CHOW and DDC conditions (n=3).