Table 2.

Concordance and Reproducibility of the Fra80 and FraGW.

Breast segmentation fat-water decomposition MRI-based breast density		Manual segmentation		Automated segmentation
		Fra80	FraGW	Fra80	FraGW
Pearson correlation coefficient with MDc (* P-values < 0.0001)a		R= 0.88*	R=0.94*	R= 0.90*	R=0.96*
Test-retest reproducibilityb	mean |Δ1–2|	0.0231	0.0149	0.0174	0.0130
	standard deviation Δ1–2	0.0282	0.0186	0.0214	0.0146
	dynamic range	0.0809~ 0.6483	0.0695~ 0.6896	0.0902~ 0.6601	0.0735~ 0.6696
	Mean |Δ1–2|/ dynamic range	4.07%	2.40%	3.05%	2.18%
	ICCd [95% confidence interval]	0.9653 [0.9251, 0.9842]	0.9846 [0.9662, 0.9930]	0.9870 [0.9715, 0.9941]	0.9901 [0.9783, 0.9955]

^acorrelation analysis was performed using Sample 1

^btest-retest analysis was performed using Sample 2.

^cMD: mammographic density

^dICC: intra-class correlation coefficient