Table 3.
Evidence for physiological importance of adult hypothalamic neurogenesis
| Reference | Location/Identity of neural progenitors |
Evidence for functional importance of newborn neurons |
Interval before physiological effect observed |
|---|---|---|---|
| [14] | Ventricular region, including tanycytes | EM analysis (synapse formation) | NA |
| [15, 16] | Parenchyma | AraC (i.c.v. infusion attenuates effects of CNTF on body weight) | 5–10 days* |
| [33] | Nestin+ tanycytes (mainly α-tanycytes) | IGF-1R KO in Nestin+ progenitor cells (increased α-tanycytes density and new born neurons) | NA |
| [36] | NG2+ parenchymal cells | Electrophysiological activity resembling immature neurons | 60 days |
| [22] | β-tanycytes (Nestin-CreERT2+) | ME focal Irradiation (selectively reduced HFD-induced gain in body weight) | 14–21 days* |
| [67] | Parenchyma, identity was not verified | AraC (i.c.v. infusion attenuates estrous-induced surge in LH release) | 28 days |
| [88] | Parenchyma | AraC, (interfered heat tolerance) | 40 days |
| [18] | Parenchyma | AraC (decreased food intake and body fat mass) | 28 days |
*
indicates time of onset of phenotype determined. All other studies analyzed at listed timepoint only.
Abbreviations used: 3V, third ventricle. AH, anterior hypothalamus. ArcN, arcuate nucleus. AVPV, anterioventral periventricular nucleus. DIO, diet-induced obesity. DMH, dorsomedial hypothalamus. EM, electron microscopy. GDX, Gonadectomy. KO, knockout. LH, lateral hypothalamus. ME, median eminence. n.s., not significant. NS, not specified. OVX, ovariectomy. PH, posterior hypothalamus. POA, preoptic area. PVN, paraventricular nucleus. SCN, suprachiasmatic nucleus. SDN, sexually dimorphic nucleus. VMH, ventromedial hypothalamus.