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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Med Res Rev. 2018 May 4;38(6):1974–2023. doi: 10.1002/med.21503

Figure 11.

Figure 11

A) Chemical structures of tetrahydroquinoline (THQ) derivatives 33–39 acting as active site, peptidomimetic inhibitors of FXIa. Inhibitors’ Ki values are provided in nM. B) Interactions between inhibitor 39 and residues in the active site of FXIa are also delineated (PDB ID: 4NA7).