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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Med Res Rev. 2018 May 4;38(6):1974–2023. doi: 10.1002/med.21503

Figure 13.

Figure 13

Chemical structures of pyrrolidine 44 and tetrahydroisoquinoline (THIQ) derivatives 45–49 acting as active site, peptidomimetic inhibitors of FXIa. Inhibitors’ Ki values are provided in nM (or μM).