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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Med Res Rev. 2018 May 4;38(6):1974–2023. doi: 10.1002/med.21503

Figure 20.

Figure 20

Chemical structures of biaryl acid derivatives 93–97 which inhibit FXIa by binding to its active site. These molecules are more potent inhibitors of FVIIa. FXIa Ki values are provided in μM. Provided also are the interactions between inhibitors 93 and 94 and residues in the active site of FXIa.