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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Med Res Rev. 2018 May 4;38(6):1974–2023. doi: 10.1002/med.21503

Figure 5. Chemical structures of aryl boronic acid derivatives that act as active site inhibitors of FXIa.

Figure 5

A) Chemical structures of inhibitors 7 and 8 are provided along with their FXIa IC50 values in μM. B) Interactions between inhibitor 8 and residues in the active site of FXIa are also delineated (PDB ID: 1ZLR).