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A) Chemical structure of β-lactam, active site inhibitor 17 of FXIa. B) The inhibition potencies (IC50 values in μM) of β-lactam 17 against a series of serine proteases. C) The acylation reaction between the β-lactam moiety of 17 and Ser195 residue of FXIa’s active site. D) The chemical structure of inhibitor 17a (Ep-7041) which just finished Phase I clinical trial.
