Table 4:
Prevalence of SIRT1 gene SNPs among the participants
| Models | Genotype frequency | All (n=568) | T2DM (n=284) | Control (n=284) | P |
|---|---|---|---|---|---|
| rs4746720 | |||||
| Additive model | TT | 177(31.16) | 93(32.75) | 84(29.58) | 0.077 |
| CT | 289(50.88) | 132(46.48) | 157(55.28) | ||
| CC | 102(17.96) | 59(20.77) | 43(15.14) | ||
| Recessive model | TT | 177(31.16) | 93(32.75) | 84(29.58) | 0.415 |
| CT+CC | 391(68.84) | 191(67.25) | 200(70.42) | ||
| Dominant model | TT+CT | 466(82.04) | 225(79.23) | 241(84.86) | 0.08 |
| CC | 102(17.96) | 59(20.77) | 43(15.14) | ||
| Co-dominant model | CT | 289(50.88) | 132(46.48) | 157(55.28) | 0.036 |
| TT+CC | 279(49.12) | 152(53.52) | 127(44.72) | ||
| rs2236319 | |||||
| Additive model | AA | 282(49.65) | 144(50.70) | 138(48.59) | 0.881 |
| AG | 231(40.67) | 113(39.79) | 118(41.55) | ||
| GG | 55(9.68) | 27(9.51) | 28(9.86) | ||
| Recessive model | AA | 282(49.65) | 144(50.70) | 138(48.59) | 0.615 |
| AG+GG | 286(50.35) | 140(49.30) | 146(51.41) | ||
| Dominant model | AA+AG | 513(90.32) | 257(90.49) | 256(90.14) | 0.887 |
| GG | 55(9.68) | 27(9.51) | 28(9.86) | ||
| Co-dominant model | AG | 231(40.67) | 113(39.79) | 118(41.55) | 0.669 |
| AA+GG | 337(59.33) | 171(60.21) | 166(58.45) | ||
| rs10509291 | |||||
| Additive model | TT | 285(50.18) | 149(52.46) | 136(47.89) | 0.426 |
| AT | 232(40.85) | 113(39.79) | 119(41.90) | ||
| AA | 51(8.98) | 22(7.75) | 29(10.21) | ||
| Recessive model | TT | 285(50.18) | 149(52.46) | 136(47.89) | 0.275 |
| AT+AA | 283(49.82) | 135(47.54) | 148(52.11) | ||
| Dominant model | TT+AT | 517(91.02) | 262(92.25) | 255(89.79) | 0.304 |
| AA | 51(8.98) | 22(7.75) | 29(10.21) | ||
| Co-dominant model | AT | 232(40.84) | 113(39.79) | 119(41.90) | 0.609 |
| TT+AA | 336(59.15) | 171(60.21) | 165(58.10) | ||
| rs10823116 | |||||
| Additive model | AA | 223(39.26) | 116(40.85) | 107(37.68) | 0.334 |
| AG | 251(44.19) | 117(41.20) | 134(47.18) | ||
| GG | 94(16.55) | 51(17.96) | 43(15.14) | ||
| Recessive model | Aa | 223(39.26) | 116(40.85) | 107(37.68) | 0.439 |
| AG+GG | 345(60.74) | 168(59.15) | 177(62.32) | ||
| Dominant model | AA+AG | 474(83.45) | 233(82.04) | 241(84.86) | 0.366 |
| GG | 94(16.55) | 51(17.96) | 43(15.14) | ||
| Co-dominant model | AG | 251(44.19) | 117(41.20) | 134(47.18) | 0.151 |
| AA+GG | 317(55.81) | 167(58.80) | 150(52.82) |