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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Gastroenterology. 2018 Jun 30;155(4):1218–1232.e24. doi: 10.1053/j.gastro.2018.06.048

Figure 2. Characterization of liver injury progression in CDE and DDC fed mice based of qLIM.

Figure 2

(A) Serum-analysis from CDE and DDC-diet fed mice indicate significant increase in alkaline-phosphatase (ALP), alanine-aminotransferase (ALT), total and direct bilirubin on 4 and 6d respectively. (B) IHC of mice on normal-chow, CDE-diet fed mice at 4d and DDC-diet fed mice at 6d shows increased number of cells (especially ductular cells) by ki67 staining; a prominent increase in Sox-9 staining in CDE and a modest increase in DDC liver sections; increased ductular-reaction by CK19 positive staining. Both CDE and DDC fed liver shows highly enriched EpCAM signal. F480 staining indicates increased macrophage activation in CDE-diet at 4d and DDC-diet at 6d compared to WT-liver.

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